The Continuous Fragility Quotient as a Model-Free Assessment for Continuous Outcomes
DOI:
https://doi.org/10.5281/zenodo.19445024Keywords:
continuous fragility quotient, CFQ, statistical fragility, continuous fragility index, continuous outcomes, fragility index, global fragility index, neutrality boundary frameworkAbstract
The continuous fragility quotient (CFQ) is a model-free fragility metric for continuous outcomes that derives entirely from the Welch t-statistic geometry, requiring only published summary statistics. Unlike the continuous fragility index (CFI), which reconstructs pseudo-observations under distributional assumptions, CFQ produces a unique, analyst-independent value normalized to [0,1] for cross-study comparison. CFQ pairs with the Meaningful Change Index (MeCI) to complete the p–fr–nb triplet for continuous outcome trials.
References
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Copyright (c) 2026 Thomas F. Heston, MD, MSc
This work is licensed under a Creative Commons Attribution 4.0 International License.
