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Thursday, June 20, 2002

Syndrome X Chest Pain Associated With Subendocardial Hypoperfusion $BlogItemSubject"; $newslink[$countera]="http://www.medjournal.com/blog/archives/2002_06_01_heartarchive.php#85185508"; ?>
This MRI study of 20 patients with syndrome X (typical angina, abnormal exercise ECG test results, and normal coronary angiogram) and 10 control patients, subendocardial hypoperfusion was demonstrated after adenosine stress. This suggests that the chest pain in syndrome X is due to myocardial ischemia. [ article ]  posted at 8:31 AM by Tom Heston, MD   


Monday, June 17, 2002

Disagreement Over the Meaning of HOPE: the Use of Ramipril to Prevent Cardiovascular Events $BlogItemSubject"; $newslink[$countera]="http://www.medjournal.com/blog/archives/2002_06_01_heartarchive.php#85177310"; ?>
Letters to the editor published in Lancet raise interesting points about the HOPE trial, which showed a significant benefit of adding ramipril to other blood pressure medications. The main authors of the HOPE trial respond convincingly. Comment: this is interesting reading. I tend to side with the authors of the HOPE trial, and believe that ramipril is a promising medication in terms of cardiovascular disease treatment and prevention. [ article ]  posted at 11:58 AM by Tom Heston, MD   


Friday, June 14, 2002

Dual Chamber Pacing Best for Sinus Node Dysfunction $BlogItemSubject"; $newslink[$countera]="http://www.medjournal.com/blog/archives/2002_06_01_heartarchive.php#85171342"; ?>
This study of 2010 patients with sinus node dysfunction found that dual chamber pacing (atrioventricular) was better than single chamber (ventricular only) pacing. There was no difference between the two groups in terms of mortality or stroke-free survival, however, those with dual chamber pacemakers had fewer signs and symptoms of heart failure, and an improved quality of life. [ article ]  posted at 3:07 PM by Tom Heston, MD   



Raloxifene Shown to Reduce Strokes and Coronary Events $BlogItemSubject"; $newslink[$countera]="http://www.medjournal.com/blog/archives/2002_06_01_heartarchive.php#85169459"; ?>
Research presented at the annual meeting of the American College of Cardiology reported that among the 1035 participants in the MORE trial, those who took 60 mg/day of raloxifene (an alternative to hormone replacement therapy) had a 40% reduction in coronary events compared with those taking a placebo. The reduction in strokes was 62%. Comment: this selective estrogen receptor modulator is very promising, and likely will be the preferred post-menopausal agent, replacing estrogen. [ Family Practice News 15 May 2002;32(10):1 ]  posted at 2:32 PM by Tom Heston, MD   


Thursday, June 13, 2002

Therapeutic Angiogenesis Shows Potential for Treating Vascular Disease $BlogItemSubject"; $newslink[$countera]="http://www.medjournal.com/blog/archives/2002_06_01_heartarchive.php#85169563"; ?>
This study of 190 patients with intermittent claudication in their legs showed a good response to the intra-arterial infusion of recombinant fibroblast growth factor-2. Comment: this growth factor may eventually help cardiac patients grow collateral vessels, decreasing the need for repeat stenting or bypass surgery. [ article ]  posted at 11:53 PM by Tom Heston, MD   


 

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