February 2, 2014

Pharmacological treatments for smoking cessation.

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Pharmacological treatments for smoking cessation.

JAMA. 2014 Jan 8;311(2):193-4

Authors: Cahill K, Stevens S, Lancaster T

CLINICAL QUESTION: Among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each?
BOTTOM LINE: Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events.

PMID: 24399558 [PubMed - indexed for MEDLINE]

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